Which of the Commonly Available and Approved Drugs in Addition to Standard of Care Can Significantly Improve the Slope of Estimated Glomerular Filtration Rate at Two Years When Compared to Standard of Care Alone in South-Asian Kidney Biopsy-proven Adult (≥18 Years) Primary IgA Nephropathy?
Conditions
- IgA Nephropathy
- Renal Insufficiency, Chronic
- IgA Vasculitis
- IGA Glomerulonephritis
Interventions
- DRUG: Oral prednisolone and SoC
- DRUG: Gut-directed budesonide and SoC
- DRUG: Mycophenolate mofetil (MMF) and SoC
- DRUG: Hydroxychloroquine and SoC
- DRUG: Non-steroidal mineralocorticoid receptor antagonist and SoC
- DRUG: SoC defined as maximal labelled or tolerated dose of angiotensin-converting enzyme inhibitor/ angiotensin receptor blocker (ACEi/ARB) & steady dose of sodium-glucose cotransporter-2 inhibitor (SGLT2i)
Sponsor
Christian Medical College, Vellore, India
Collaborators
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