# Which of the Commonly Available and Approved Drugs in Addition to Standard of Care Can Significantly Improve the Slope of Estimated Glomerular Filtration Rate at Two Years When Compared to Standard of Care Alone in South-Asian Kidney Biopsy-proven Adult (≥18 Years) Primary IgA Nephropathy?

> **NCT06676384** · PHASE4 · RECRUITING · sponsor: **Christian Medical College, Vellore, India** · enrollment: 585 (estimated)

## Conditions studied

- IgA Nephropathy
- Renal Insufficiency, Chronic
- IgA Vasculitis
- IGA Glomerulonephritis

## Interventions

- **DRUG:** Oral prednisolone and SoC
- **DRUG:** Gut-directed budesonide and SoC
- **DRUG:** Mycophenolate mofetil (MMF) and SoC
- **DRUG:** Hydroxychloroquine and SoC
- **DRUG:** Non-steroidal mineralocorticoid receptor antagonist and SoC
- **DRUG:** SoC defined as maximal labelled or tolerated dose of angiotensin-converting enzyme inhibitor/ angiotensin receptor blocker (ACEi/ARB) & steady dose of sodium-glucose cotransporter-2 inhibitor (SGLT2i)

## Key facts

- **NCT ID:** NCT06676384
- **Lead sponsor:** Christian Medical College, Vellore, India
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-02-15
- **Primary completion:** 2029-08
- **Final completion:** 2029-08
- **Target enrollment:** 585 (ESTIMATED)
- **Last updated:** 2025-07-14

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06676384

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06676384, "Which of the Commonly Available and Approved Drugs in Addition to Standard of Care Can Significantly Improve the Slope of Estimated Glomerular Filtration Rate at Two Years When Compared to Standard of Care Alone in South-Asian Kidney Biopsy-proven Adult (≥18 Years) Primary IgA Nephropathy?". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT06676384. Licensed CC0.

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