# Safety and Immunogenicity Study of Three mRNAs Encoding HIV Immunogens in Adult Participants Without HIV and in Overall Good Health in South Africa.

> **NCT06694753** · PHASE1 · RECRUITING · sponsor: **International AIDS Vaccine Initiative** · enrollment: 96 (estimated)

## Conditions studied

- HIV Infections

## Interventions

- **BIOLOGICAL:** mRNA-1645-eODGT8
- **BIOLOGICAL:** mRNA-1645-CoreG28v2
- **BIOLOGICAL:** mRNA-1645-N332GT5
- **BIOLOGICAL:** Placebo

## Key facts

- **NCT ID:** NCT06694753
- **Lead sponsor:** International AIDS Vaccine Initiative
- **Sponsor class:** NETWORK
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-12-15
- **Primary completion:** 2026-12-08
- **Final completion:** 2027-03-31
- **Target enrollment:** 96 (ESTIMATED)
- **Last updated:** 2026-05-07

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06694753

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06694753, "Safety and Immunogenicity Study of Three mRNAs Encoding HIV Immunogens in Adult Participants Without HIV and in Overall Good Health in South Africa.". Retrieved via AI Analytics 2026-07-08 from https://api.ai-analytics.org/clinical/NCT06694753. Licensed CC0.

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