# Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric Disorder

> **NCT06704594** · PHASE4 · RECRUITING · sponsor: **Johns Hopkins University** · enrollment: 288 (estimated)

## Conditions studied

- Premenstrual Dysphoric Disorder (PMDD)

## Interventions

- **DRUG:** sertraline 50 mg daily
- **DRUG:** Placebo Oral Tablet

## Key facts

- **NCT ID:** NCT06704594
- **Lead sponsor:** Johns Hopkins University
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-05-14
- **Primary completion:** 2029-07-01
- **Final completion:** 2029-07-01
- **Target enrollment:** 288 (ESTIMATED)
- **Last updated:** 2026-05-07

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06704594

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06704594, "Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric Disorder". Retrieved via AI Analytics 2026-07-23 from https://api.ai-analytics.org/clinical/NCT06704594. Licensed CC0.

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