# PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study

> **NCT06713616** · PHASE3 · RECRUITING · sponsor: **Yale University** · enrollment: 400 (estimated)

## Conditions studied

- Depression

## Interventions

- **DRUG:** Racemic ketamine
- **DRUG:** Spravato (Esketamine)

## Key facts

- **NCT ID:** NCT06713616
- **Lead sponsor:** Yale University
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-01-27
- **Primary completion:** 2030-12-31
- **Final completion:** 2030-12-31
- **Target enrollment:** 400 (ESTIMATED)
- **Last updated:** 2026-05-05

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06713616

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06713616, "PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study". Retrieved via AI Analytics 2026-06-23 from https://api.ai-analytics.org/clinical/NCT06713616. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*