# Feasibility of Closed-loop TCI Based on New EEG Baseline in the Presence of Low Dose of Esketamine

> **NCT06729892** · PHASE4 · NOT_YET_RECRUITING · sponsor: **bo xu** · enrollment: 120 (estimated)

## Conditions studied

- General Anesthesia With Propofol
- Closed-Loop

## Interventions

- **DRUG:** Esketamine at low dose
- **DEVICE:** new BIS baseline
- **DRUG:** an equivalent dose of saline
- **DEVICE:** original BIS baseline

## Key facts

- **NCT ID:** NCT06729892
- **Lead sponsor:** bo xu
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2025-01-20
- **Primary completion:** 2025-04-30
- **Final completion:** 2025-05-30
- **Target enrollment:** 120 (ESTIMATED)
- **Last updated:** 2025-01-13


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06729892

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06729892, "Feasibility of Closed-loop TCI Based on New EEG Baseline in the Presence of Low Dose of Esketamine". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT06729892. Licensed CC0.

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