# A Study to Evaluate the Effects of Lithium, Valproic Acid, and Lamotrigine on the Pharmacokinetics of KarXT and Effects of KarXT on the Pharmacokinetics of Lithium, Valproic Acid, and Lamotrigine in Healthy Participants

> **NCT06729970** · PHASE1 · COMPLETED · sponsor: **Karuna Therapeutics, Inc., a Bristol Myers Squibb company** · enrollment: 133 (actual)

## Conditions studied

- Healthy Volunteers

## Interventions

- **DRUG:** Xanomeline/Trospium Chloride
- **DRUG:** Lithium
- **DRUG:** Valproic Acid
- **DRUG:** Lamotrigine

## Key facts

- **NCT ID:** NCT06729970
- **Lead sponsor:** Karuna Therapeutics, Inc., a Bristol Myers Squibb company
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2024-12-26
- **Primary completion:** 2026-01-23
- **Final completion:** 2026-01-23
- **Target enrollment:** 133 (ACTUAL)
- **Last updated:** 2026-02-24


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06729970

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06729970, "A Study to Evaluate the Effects of Lithium, Valproic Acid, and Lamotrigine on the Pharmacokinetics of KarXT and Effects of KarXT on the Pharmacokinetics of Lithium, Valproic Acid, and Lamotrigine in Healthy Participants". Retrieved via AI Analytics 2026-06-09 from https://api.ai-analytics.org/clinical/NCT06729970. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*