Allogeneic CMV-Specific CD19-CAR T Cells Plus CMV-MVA Triplex Vaccine After Matched Related Donor Hematopoietic Cell Transplant for the Treatment of Patients With High-Risk Acute Lymphoblastic Leukemia

Conditions

• Acute Lymphoblastic Leukemia

Interventions

• PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation
• BIOLOGICAL: Anti-CD19-CAR CMV-specific T-lymphocytes
• PROCEDURE: Biospecimen Collection
• PROCEDURE: Bone Marrow Aspiration
• PROCEDURE: Bone Marrow Biopsy
• PROCEDURE: Computed Tomography
• PROCEDURE: Echocardiography
• PROCEDURE: Leukapheresis
• PROCEDURE: Lumbar Puncture
• PROCEDURE: Magnetic Resonance Imaging
• BIOLOGICAL: Multi-peptide CMV-Modified Vaccinia Ankara Vaccine
• PROCEDURE: Multigated Acquisition Scan
• PROCEDURE: Positron Emission Tomography
• OTHER: Transplant Conditioning
• PROCEDURE: X-Ray Imaging

Sponsor

City of Hope Medical Center

Collaborators

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