# Comparing Radiation Therapy to Usual Treatment for Patients With High-Risk Bone Metastases That Are Not Causing Pain, PREEMPT Trial

> **NCT06745024** · PHASE3 · ACTIVE_NOT_RECRUITING · sponsor: **NRG Oncology** · enrollment: 280 (estimated)

## Conditions studied

- Metastatic Malignant Neoplasm in the Bone
- Metastatic Malignant Solid Neoplasm

## Interventions

- **OTHER:** Best Practice
- **PROCEDURE:** Biospecimen Collection
- **OTHER:** Bone Metastases Treatment
- **PROCEDURE:** Computed Tomography
- **PROCEDURE:** Conventional Radiotherapy
- **PROCEDURE:** Magnetic Resonance Imaging
- **OTHER:** Patient Observation
- **OTHER:** Questionnaire Administration
- **RADIATION:** Stereotactic Body Radiation Therapy

## Key facts

- **NCT ID:** NCT06745024
- **Lead sponsor:** NRG Oncology
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2025-05-07
- **Primary completion:** 2029-02-01
- **Final completion:** 2029-02-01
- **Target enrollment:** 280 (ESTIMATED)
- **Last updated:** 2026-05-04


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06745024

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06745024, "Comparing Radiation Therapy to Usual Treatment for Patients With High-Risk Bone Metastases That Are Not Causing Pain, PREEMPT Trial". Retrieved via AI Analytics 2026-06-09 from https://api.ai-analytics.org/clinical/NCT06745024. Licensed CC0.

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