# Effect of Psilocybin Only and Psilocybin Assisted Cognitive Behavioral Therapy in the Management of Major Depressive Disorder and Associated Metabolic, Immune, Inflammatory, Neuroplasticity and Electrical Activity Markers

> **NCT06746441** · PHASE2 · COMPLETED · sponsor: **Khyber Medical University Peshawar** · enrollment: 60 (actual)

## Conditions studied

- Major Depressive Disorder

## Interventions

- **DRUG:** Psilocybin
- **BEHAVIORAL:** Cognitive Behavioral Therapy (CBT)

## Key facts

- **NCT ID:** NCT06746441
- **Lead sponsor:** Khyber Medical University Peshawar
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2024-12-01
- **Primary completion:** 2025-06-01
- **Final completion:** 2025-07-30
- **Target enrollment:** 60 (ACTUAL)
- **Last updated:** 2025-09-02


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06746441

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06746441, "Effect of Psilocybin Only and Psilocybin Assisted Cognitive Behavioral Therapy in the Management of Major Depressive Disorder and Associated Metabolic, Immune, Inflammatory, Neuroplasticity and Electrical Activity Markers". Retrieved via AI Analytics 2026-06-23 from https://api.ai-analytics.org/clinical/NCT06746441. Licensed CC0.

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