Ruxolitinib Based GVHD Prophylaxis Regimen Before, During, and After Hematopoietic Cell Transplantation in Older Adult Patients With Acquired Aplastic Anemia

Conditions

• Aplastic Anemia

Interventions

• PROCEDURE: Biospecimen Collection
• PROCEDURE: Bone Marrow Aspiration
• PROCEDURE: Bone Marrow Biopsy
• PROCEDURE: Bone Marrow Transplantation
• PROCEDURE: Computed Tomography
• DRUG: Cyclosporine
• DRUG: Fludarabine
• DRUG: Granulocyte Colony-Stimulating Factor
• DRUG: Mycophenolate Mofetil
• PROCEDURE: Peripheral Blood Stem Cell Transplantation
• DRUG: Ruxolitinib
• DRUG: Sirolimus
• RADIATION: Total-Body Irradiation
• PROCEDURE: Multigated Acquisition Scan
• PROCEDURE: Echocardiography

Sponsor

Fred Hutchinson Cancer Center

Collaborators

• [object Object]