# Ruxolitinib Based GVHD Prophylaxis Regimen Before, During, and After Hematopoietic Cell Transplantation in Older Adult Patients With Acquired Aplastic Anemia

> **NCT06752694** · PHASE2 · RECRUITING · sponsor: **Fred Hutchinson Cancer Center** · enrollment: 20 (estimated)

## Conditions studied

- Aplastic Anemia

## Interventions

- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Bone Marrow Aspiration
- **PROCEDURE:** Bone Marrow Biopsy
- **PROCEDURE:** Bone Marrow Transplantation
- **PROCEDURE:** Computed Tomography
- **DRUG:** Cyclosporine
- **DRUG:** Fludarabine
- **DRUG:** Granulocyte Colony-Stimulating Factor
- **DRUG:** Mycophenolate Mofetil
- **PROCEDURE:** Peripheral Blood Stem Cell Transplantation
- **DRUG:** Ruxolitinib
- **DRUG:** Sirolimus
- **RADIATION:** Total-Body Irradiation
- **PROCEDURE:** Multigated Acquisition Scan
- **PROCEDURE:** Echocardiography

## Key facts

- **NCT ID:** NCT06752694
- **Lead sponsor:** Fred Hutchinson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-09-25
- **Primary completion:** 2027-12-31
- **Final completion:** 2027-12-31
- **Target enrollment:** 20 (ESTIMATED)
- **Last updated:** 2026-03-12

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06752694

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06752694, "Ruxolitinib Based GVHD Prophylaxis Regimen Before, During, and After Hematopoietic Cell Transplantation in Older Adult Patients With Acquired Aplastic Anemia". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT06752694. Licensed CC0.

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