Enfortumab Vedotin and Pembrolizumab With Cystectomy and/or Ureterectomy for Locally Advanced or Metastatic Bladder and Upper Urothelial Tract Cancer, CAST-AI Trial

NCT06764095 · clinicaltrials.gov ↗

PHASE4

Phase

RECRUITING

Status

75

Enrollment

OTHER

Sponsor class

Conditions

Locally Advanced Bladder Urothelial Carcinoma
Locally Advanced Renal Pelvis and Ureter Urothelial Carcinoma
Metastatic Bladder Urothelial Carcinoma
Metastatic Renal Pelvis and Ureter Urothelial Carcinoma
Stage III Bladder Cancer AJCC v8
Stage IV Bladder Cancer AJCC v8
Stage IV Renal Pelvis and Ureter Cancer AJCC v8

Interventions

PROCEDURE: Biospecimen Collection
PROCEDURE: Computed Tomography
PROCEDURE: Cystectomy
DRUG: Enfortumab Vedotin
PROCEDURE: Local Therapy
PROCEDURE: Magnetic Resonance Imaging
BIOLOGICAL: Pembrolizumab
PROCEDURE: Positron Emission Tomography
OTHER: Questionnaire Administration
PROCEDURE: Ureterectomy

Sponsor

Mayo Clinic