# FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery

> **NCT06780787** · PHASE2 · RECRUITING · sponsor: **City of Hope Medical Center** · enrollment: 26 (estimated)

## Conditions studied

- Rectal Adenocarcinoma
- Stage IIA Rectal Cancer AJCC v8
- Stage III Rectal Cancer AJCC v8

## Interventions

- **BIOLOGICAL:** Balstilimab
- **PROCEDURE:** Biospecimen Collection
- **BIOLOGICAL:** Botensilimab
- **DRUG:** Capecitabine
- **PROCEDURE:** Computed Tomography
- **PROCEDURE:** Digital Rectal Examination
- **PROCEDURE:** Endoscopic Biopsy
- **DRUG:** Fluorouracil
- **DRUG:** Leucovorin Calcium
- **PROCEDURE:** Magnetic Resonance Imaging
- **DRUG:** Oxaliplatin
- **RADIATION:** Radiation Therapy
- **PROCEDURE:** Sigmoidoscopy

## Key facts

- **NCT ID:** NCT06780787
- **Lead sponsor:** City of Hope Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-05-20
- **Primary completion:** 2027-11-05
- **Final completion:** 2027-11-05
- **Target enrollment:** 26 (ESTIMATED)
- **Last updated:** 2025-06-26

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06780787

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06780787, "FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT06780787. Licensed CC0.

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