# Odronextamab for Relapsed and Refractory Large B-cell Lymphomas Before CAR-T

> **NCT06784726** · PHASE2 · RECRUITING · sponsor: **University of Washington** · enrollment: 27 (estimated)

## Conditions studied

- Recurrent Diffuse Large B-Cell Lymphoma
- Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
- Recurrent Grade 3b Follicular Lymphoma
- Recurrent High Grade B-Cell Lymphoma
- Recurrent Primary Mediastinal Large B-Cell Lymphoma
- Recurrent Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma
- Refractory Diffuse Large B-Cell Lymphoma
- Refractory Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
- Refractory Grade 3b Follicular Lymphoma
- Refractory High Grade B-Cell Lymphoma
- Refractory Primary Mediastinal Large B-Cell Lymphoma
- Refractory Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

## Interventions

- **BIOLOGICAL:** Odronextamab
- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Bone Marrow Aspiration
- **PROCEDURE:** Bone Marrow Biopsy
- **BIOLOGICAL:** Chimeric Antigen Receptor T-Cell Therapy
- **PROCEDURE:** Computed Tomography
- **PROCEDURE:** Leukapheresis
- **PROCEDURE:** Lumbar Puncture
- **PROCEDURE:** Positron Emission Tomography
- **OTHER:** Questionnaire Administration
- **PROCEDURE:** Biopsy Procedure

## Key facts

- **NCT ID:** NCT06784726
- **Lead sponsor:** University of Washington
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-09-04
- **Primary completion:** 2028-04-10
- **Final completion:** 2033-04-11
- **Target enrollment:** 27 (ESTIMATED)
- **Last updated:** 2026-05-06

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06784726

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06784726, "Odronextamab for Relapsed and Refractory Large B-cell Lymphomas Before CAR-T". Retrieved via AI Analytics 2026-06-09 from https://api.ai-analytics.org/clinical/NCT06784726. Licensed CC0.

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