# Investigating the Protective Impact of LY-2940094 on Stress-induced Depression- and Anxiety-related Phenotypes in Humans

> **NCT06786637** · PHASE2 · WITHDRAWN · sponsor: **Mclean Hospital**

## Conditions studied

- Depression - Major Depressive Disorder
- Anxiety
- Stress

## Interventions

- **DRUG:** Nociceptin Receptor Antagonist (LY-2940094)
- **DEVICE:** DS8R Biphasic Constant Current Stimulator

## Key facts

- **NCT ID:** NCT06786637
- **Lead sponsor:** Mclean Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** WITHDRAWN
- **Start date:** 2025-06
- **Primary completion:** 2026-01
- **Final completion:** 2026-08
- **Target enrollment:** 0 (ACTUAL)
- **Why stopped:** PI transferred to a different research institution and local institution would not allow to continue the study. Transfer of the study to a different study site not possible because of unique requirements of resources (e.g., nociceptin anatagonist)
- **Last updated:** 2025-09-25

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06786637

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06786637, "Investigating the Protective Impact of LY-2940094 on Stress-induced Depression- and Anxiety-related Phenotypes in Humans". Retrieved via AI Analytics 2026-06-09 from https://api.ai-analytics.org/clinical/NCT06786637. Licensed CC0.

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