# Effects of Face Mask Continuous Positive Airway Pressure Vs. Noninvasive Ventilation Vs. High-flow Nasal Oxygen on Intubation-free Survival in Acute Hypoxemic Respiratory Failure: the TRIPOD Randomized Clinical Trial

> **NCT06795971** · NA · RECRUITING · sponsor: **Southeast University, China** · enrollment: 1300 (estimated)

## Conditions studied

- Acute Hypoxemic Respiratory Failure
- High-Flow Nasal Oxygen Therapy
- Noninvasive Ventilation
- Continuous Positive Airway Pressure (CPAP)

## Interventions

- **DEVICE:** Continuous Positive Airway Pressure
- **DEVICE:** High-flow nasal oxygen
- **DEVICE:** Non-invasive ventilation

## Key facts

- **NCT ID:** NCT06795971
- **Lead sponsor:** Southeast University, China
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-01-23
- **Primary completion:** 2027-10-31
- **Final completion:** 2027-12-31
- **Target enrollment:** 1300 (ESTIMATED)
- **Last updated:** 2025-02-26


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06795971

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06795971, "Effects of Face Mask Continuous Positive Airway Pressure Vs. Noninvasive Ventilation Vs. High-flow Nasal Oxygen on Intubation-free Survival in Acute Hypoxemic Respiratory Failure: the TRIPOD Randomized Clinical Trial". Retrieved via AI Analytics 2026-08-21 from https://api.ai-analytics.org/clinical/NCT06795971. Licensed CC0.

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