# Intrathecal PD-1/VEGF Bispecific Antibody Plus Pemetrexed for Leptomeningeal Metastasis

> **NCT06809517** · PHASE1,PHASE2 · RECRUITING · sponsor: **Guangzhou Medical University** · enrollment: 34 (estimated)

## Conditions studied

- Leptomeningeal Metastasis
- Intrathecal Drug Delivery

## Interventions

- **DRUG:** AK112
- **DRUG:** Pemetrexed (Alimta)

## Key facts

- **NCT ID:** NCT06809517
- **Lead sponsor:** Guangzhou Medical University
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-03-18
- **Primary completion:** 2026-03-01
- **Final completion:** 2026-05-01
- **Target enrollment:** 34 (ESTIMATED)
- **Last updated:** 2025-05-20


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06809517

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06809517, "Intrathecal PD-1/VEGF Bispecific Antibody Plus Pemetrexed for Leptomeningeal Metastasis". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT06809517. Licensed CC0.

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