Vedolizumab Plus Post-transplant Cyclophosphamide and Short Course Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation After Reduced Intensity Conditioning
Conditions
- Acute Lymphoblastic Leukemia
- Acute Myeloid Leukemia
- Chronic Myelomonocytic Leukemia
- Graft Versus Host Disease
- Myelodysplastic Syndrome
- Myeloproliferative Neoplasm
Interventions
- PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation
- PROCEDURE: Biospecimen Collection
- PROCEDURE: Bone Marrow Biopsy
- PROCEDURE: Computed Tomography
- DRUG: Cyclophosphamide
- PROCEDURE: Echocardiography
- DRUG: Fludarabine
- DRUG: Melphalan
- PROCEDURE: Multigated Acquisition Scan
- OTHER: Questionnaire Administration
- DRUG: Tacrolimus
- BIOLOGICAL: Vedolizumab
Sponsor
City of Hope Medical Center
Collaborators