# The Effect of Amantadine as add-on Therapy for Motor Fluctuations in Advanced Parkinson's Disease: a Randomized Double-blinded Placebo-controlled Trial

> **NCT06817200** · PHASE2 · NOT_YET_RECRUITING · sponsor: **University Hospital, Toulouse** · enrollment: 132 (estimated)

## Conditions studied

- Parkinson Disease (PD)

## Interventions

- **DRUG:** Amantadine (100mg) as add on therapy.
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT06817200
- **Lead sponsor:** University Hospital, Toulouse
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2025-05-01
- **Primary completion:** 2025-05-01
- **Final completion:** 2027-08-31
- **Target enrollment:** 132 (ESTIMATED)
- **Last updated:** 2025-02-10


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06817200

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06817200, "The Effect of Amantadine as add-on Therapy for Motor Fluctuations in Advanced Parkinson's Disease: a Randomized Double-blinded Placebo-controlled Trial". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT06817200. Licensed CC0.

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