# PRophylaxis Against Early VENTilator-associated Infections in Acute Brain Injury

> **NCT06819592** · PHASE3 · RECRUITING · sponsor: **The George Institute** · enrollment: 3300 (estimated)

## Conditions studied

- All-cause Mortality
- Quality of Life
- Disability, Intellectual
- Neurological Disorder
- Acute Brain Injury
- Ventilation, Mechanical
- Intensive Care Medicine

## Interventions

- **DRUG:** Ceftriaxone 2g diluted in >200ml 0.9%sodium chloride
- **DRUG:** Placebo comparator - no ceftriaxone

## Key facts

- **NCT ID:** NCT06819592
- **Lead sponsor:** The George Institute
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-10-30
- **Primary completion:** 2029-08
- **Final completion:** 2029-12
- **Target enrollment:** 3300 (ESTIMATED)
- **Last updated:** 2026-02-19


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06819592

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06819592, "PRophylaxis Against Early VENTilator-associated Infections in Acute Brain Injury". Retrieved via AI Analytics 2026-08-08 from https://api.ai-analytics.org/clinical/NCT06819592. Licensed CC0.

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