Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing Sarcoma Who Have Cancer That Has Spread to Other Parts of the Body

Conditions

• CIC-Rearranged Sarcoma
• Metastatic Ewing Sarcoma
• Metastatic High Grade Sarcoma
• Metastatic Undifferentiated Round Cell Sarcoma
• Metastatic Undifferentiated Sarcoma, Not Otherwise Specified
• Round Cell Sarcoma With EWSR1-non-ETS Fusion
• Sarcoma With BCOR Genetic Alterations

Interventions

• PROCEDURE: Biopsy Procedure
• PROCEDURE: Biospecimen Collection
• PROCEDURE: Bone Marrow Aspiration
• PROCEDURE: Bone Marrow Biopsy
• PROCEDURE: Computed Tomography
• DRUG: Cyclophosphamide
• DRUG: Doxorubicin Hydrochloride
• PROCEDURE: Echocardiography Test
• DRUG: Etoposide
• OTHER: Fludeoxyglucose F-18
• DRUG: Ifosfamide
• DRUG: Irinotecan Hydrochloride
• PROCEDURE: Magnetic Resonance Imaging
• PROCEDURE: Positron Emission Tomography
• OTHER: Questionnaire Administration
• RADIATION: Radiation Therapy
• DRUG: Regorafenib
• PROCEDURE: Surgical Procedure
• DRUG: Vincristine Sulfate

Sponsor

Children's Oncology Group