# Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing Sarcoma Who Have Cancer That Has Spread to Other Parts of the Body

> **NCT06820957** · PHASE2,PHASE3 · ACTIVE_NOT_RECRUITING · sponsor: **Children's Oncology Group** · enrollment: 437 (estimated)

## Conditions studied

- CIC-Rearranged Sarcoma
- Metastatic Ewing Sarcoma
- Metastatic High Grade Sarcoma
- Metastatic Undifferentiated Round Cell Sarcoma
- Metastatic Undifferentiated Sarcoma, Not Otherwise Specified
- Round Cell Sarcoma With EWSR1-non-ETS Fusion
- Sarcoma With BCOR Genetic Alterations

## Interventions

- **PROCEDURE:** Biopsy Procedure
- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Bone Marrow Aspiration
- **PROCEDURE:** Bone Marrow Biopsy
- **PROCEDURE:** Computed Tomography
- **DRUG:** Cyclophosphamide
- **DRUG:** Doxorubicin Hydrochloride
- **PROCEDURE:** Echocardiography Test
- **DRUG:** Etoposide
- **OTHER:** Fludeoxyglucose F-18
- **DRUG:** Ifosfamide
- **DRUG:** Irinotecan Hydrochloride
- **PROCEDURE:** Magnetic Resonance Imaging
- **PROCEDURE:** Positron Emission Tomography
- **OTHER:** Questionnaire Administration
- **RADIATION:** Radiation Therapy
- **DRUG:** Regorafenib
- **PROCEDURE:** Surgical Procedure
- **DRUG:** Vincristine Sulfate

## Key facts

- **NCT ID:** NCT06820957
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE2,PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2025-11-10
- **Primary completion:** 2027-12-31
- **Final completion:** 2027-12-31
- **Target enrollment:** 437 (ESTIMATED)
- **Last updated:** 2026-02-17


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06820957

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06820957, "Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing Sarcoma Who Have Cancer That Has Spread to Other Parts of the Body". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT06820957. Licensed CC0.

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