# Therapeutic Strategies to Reduce Endothelial Ischemia-reperfusion Injury

> **NCT06825143** · EARLY_PHASE1 · NOT_YET_RECRUITING · sponsor: **Gary Van Guilder** · enrollment: 68 (estimated)

## Conditions studied

- Metabolic Syndrome
- Vascular Injury
- Ischemic Preconditioning
- Endothelial Function (reactive Hyperemia)
- Endothelial Dysfunction

## Interventions

- **PROCEDURE:** Ischemic preconditioning
- **DRUG:** Intravenous lactate infusion
- **PROCEDURE:** No ischemic preconditioning (control)
- **DRUG:** Normal Saline Infusion (Placebo)
- **COMBINATION_PRODUCT:** Ischemic preconditioning and intravenous lactate

## Key facts

- **NCT ID:** NCT06825143
- **Lead sponsor:** Gary Van Guilder
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-10-01
- **Primary completion:** 2029-09-30
- **Final completion:** 2030-06-30
- **Target enrollment:** 68 (ESTIMATED)
- **Last updated:** 2025-02-13


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06825143

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06825143, "Therapeutic Strategies to Reduce Endothelial Ischemia-reperfusion Injury". Retrieved via AI Analytics 2026-06-23 from https://api.ai-analytics.org/clinical/NCT06825143. Licensed CC0.

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