# Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV- Individuals With a History of Injection Drug Use

> **NCT06829238** · PHASE4 · RECRUITING · sponsor: **University of Alabama at Birmingham** · enrollment: 100 (estimated)

## Conditions studied

- Systemic Inflammation
- Immune Dysregulation
- Injection Drug Use
- HIV

## Interventions

- **DRUG:** Metformin
- **DRUG:** Placebo
- **BIOLOGICAL:** Jynneos
- **BIOLOGICAL:** Capvaxvie

## Key facts

- **NCT ID:** NCT06829238
- **Lead sponsor:** University of Alabama at Birmingham
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-04-07
- **Primary completion:** 2028-11-30
- **Final completion:** 2029-11-30
- **Target enrollment:** 100 (ESTIMATED)
- **Last updated:** 2026-04-22

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06829238

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06829238, "Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV- Individuals With a History of Injection Drug Use". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT06829238. Licensed CC0.

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