# Papaverine in Combination With Radiation Therapy for the Treatment of Locally Advanced Rectal Cancer, DINOMITE Trial

> **NCT06834126** · PHASE1 · RECRUITING · sponsor: **City of Hope Medical Center** · enrollment: 36 (estimated)

## Conditions studied

- Locally Advanced Rectal Adenocarcinoma
- Stage II Rectal Cancer AJCC v8
- Stage III Rectal Cancer AJCC v8

## Interventions

- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Computed Tomography
- **DRUG:** Consolidation Therapy
- **PROCEDURE:** Functional Magnetic Resonance Imaging
- **PROCEDURE:** Gastrointestinal Endoscopy
- **PROCEDURE:** Magnetic Resonance Imaging
- **DRUG:** Papaverine
- **RADIATION:** Radiation Therapy
- **PROCEDURE:** Total Mesorectal Excision

## Key facts

- **NCT ID:** NCT06834126
- **Lead sponsor:** City of Hope Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-04-07
- **Primary completion:** 2028-09-19
- **Final completion:** 2028-09-19
- **Target enrollment:** 36 (ESTIMATED)
- **Last updated:** 2025-07-18

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06834126

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06834126, "Papaverine in Combination With Radiation Therapy for the Treatment of Locally Advanced Rectal Cancer, DINOMITE Trial". Retrieved via AI Analytics 2026-06-09 from https://api.ai-analytics.org/clinical/NCT06834126. Licensed CC0.

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