# Assessment of the PEEP Responsiveness to Titrate End-expiratory Pressure and of the Need for Muscle Relaxation During Prone Positioning in Moderate-to-severe Acute Respiratory Distress Syndrome: A Master Protocol

> **NCT06849570** · NA · NOT_YET_RECRUITING · sponsor: **Assistance Publique - Hôpitaux de Paris** · enrollment: 1200 (estimated)

## Conditions studied

- Acute Respiratory Distress Syndrome (ARDS)
- Intensive Care Units (ICUs)

## Interventions

- **OTHER:** Minimal distension
- **OTHER:** Maximal Recruitment
- **OTHER:** Prone position + early NMBAs
- **OTHER:** Prone position + rescue NMBAs

## Key facts

- **NCT ID:** NCT06849570
- **Lead sponsor:** Assistance Publique - Hôpitaux de Paris
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2025-04-01
- **Primary completion:** 2028-04-01
- **Final completion:** 2029-04-01
- **Target enrollment:** 1200 (ESTIMATED)
- **Last updated:** 2025-02-27


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06849570

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06849570, "Assessment of the PEEP Responsiveness to Titrate End-expiratory Pressure and of the Need for Muscle Relaxation During Prone Positioning in Moderate-to-severe Acute Respiratory Distress Syndrome: A Master Protocol". Retrieved via AI Analytics 2026-06-26 from https://api.ai-analytics.org/clinical/NCT06849570. Licensed CC0.

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