# A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation

> **NCT06859424** · PHASE2 · RECRUITING · sponsor: **Center for International Blood and Marrow Transplant Research** · enrollment: 358 (estimated)

## Conditions studied

- AML (Acute Myelogenous Leukemia)
- Acute Lymphoid Leukemia (ALL)
- Acute Leukemia (Category)
- MDS (Myelodysplastic Syndrome)
- CML (Chronic Myelogenous Leukemia)
- CLL (Chronic Lymphocytic Leukemia)
- Prolymphocyctic Leukemia
- Chronic Myelomonocytic Leukemia (CMML)
- Myeloproliferative Neoplasm (MPN)
- Lymphoma
- Myelofibrosis

## Interventions

- **DRUG:** Conditioning Regimen A
- **DRUG:** Conditioning Regimen B
- **DRUG:** Conditioning Regimen C
- **DRUG:** Conditioning Regimen D
- **DRUG:** Conditioning Regimen E
- **PROCEDURE:** Hematopoietic Cell Transplantation
- **DRUG:** PTCy (50 mg/kg D3, D4)
- **DRUG:** PTCy (25 mg/kg D3, D4)
- **DRUG:** Post-transplant Tacrolimus
- **DRUG:** Post-transplant Mycophenolate mofetil
- **DRUG:** Post-transplant Abatacept
- **DRUG:** Post-transplant Ruxolitinib
- **DRUG:** Supportive Care: Growth Factors
- **PROCEDURE:** Supportive Care: Blood Products
- **OTHER:** Supportive Care: Infection Prophylaxis
- **OTHER:** Supportive Care: Intravenous immune globulin (IVIG)
- **DRUG:** Supportive Care: Seizure prophylaxis
- **OTHER:** Supportive Care: Monitoring and management of CRS
- **OTHER:** Supportive Care: Prophylaxis against infections
- **DRUG:** Supportive Care: Prophylaxis against infections

## Key facts

- **NCT ID:** NCT06859424
- **Lead sponsor:** Center for International Blood and Marrow Transplant Research
- **Sponsor class:** NETWORK
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-07-25
- **Primary completion:** 2028-06
- **Final completion:** 2028-06
- **Target enrollment:** 358 (ESTIMATED)
- **Last updated:** 2026-03-17

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06859424

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06859424, "A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation". Retrieved via AI Analytics 2026-06-23 from https://api.ai-analytics.org/clinical/NCT06859424. Licensed CC0.

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