# Dexmedetomidine-Esketamine Combination and Sleep Disturbances After Major Noncardiac Surgery

> **NCT06859892** · PHASE4 · RECRUITING · sponsor: **Peking University First Hospital** · enrollment: 476 (estimated)

## Conditions studied

- Adults
- Major Noncardiac Surgery
- Dexmedetomidine
- Esketamine
- Postoperative Sleep Disturbances

## Interventions

- **DRUG:** Dexmedetomidine-esketamine combination
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT06859892
- **Lead sponsor:** Peking University First Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-03-18
- **Primary completion:** 2026-11
- **Final completion:** 2026-12
- **Target enrollment:** 476 (ESTIMATED)
- **Last updated:** 2025-03-19


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06859892

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06859892, "Dexmedetomidine-Esketamine Combination and Sleep Disturbances After Major Noncardiac Surgery". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT06859892. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*