# Efficacy and Safety Comparison of Cofrogliptin Add-on Versus Metformin Dose-escalation in Type 2 Diabetes Patients Inadequately Controlled With SGLT-2 Inhibitors Plus Low-Dose Metformin:A Multicenter, Open-Label Trial

> **NCT06863532** · NA · RECRUITING · sponsor: **Second Affiliated Hospital, School of Medicine, Zhejiang University** · enrollment: 80 (estimated)

## Conditions studied

- Type 2 Diabetes

## Interventions

- **DRUG:** Cofrogliptin+SGLT2i+Metformin
- **DRUG:** Metformin dose escalation

## Key facts

- **NCT ID:** NCT06863532
- **Lead sponsor:** Second Affiliated Hospital, School of Medicine, Zhejiang University
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-03-30
- **Primary completion:** 2026-06-30
- **Final completion:** 2026-09-01
- **Target enrollment:** 80 (ESTIMATED)
- **Last updated:** 2025-03-07

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06863532

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06863532, "Efficacy and Safety Comparison of Cofrogliptin Add-on Versus Metformin Dose-escalation in Type 2 Diabetes Patients Inadequately Controlled With SGLT-2 Inhibitors Plus Low-Dose Metformin:A Multicenter, Open-Label Trial". Retrieved via AI Analytics 2026-06-08 from https://api.ai-analytics.org/clinical/NCT06863532. Licensed CC0.

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