# Fibrosis-Modulating Effects of Metformin and Pirfenidone in Oral Submucous Fibrosis

> **NCT06871904** · PHASE1,PHASE2 · COMPLETED · sponsor: **Ziauddin University** · enrollment: 45 (actual)

## Conditions studied

- Oral Submucous Fibrosis

## Interventions

- **DRUG:** Metformin Hydrochloride 500Mg Tablet
- **DRUG:** Pirfenidone (PFD)
- **DRUG:** Beclomaethasone and Vitamin E

## Key facts

- **NCT ID:** NCT06871904
- **Lead sponsor:** Ziauddin University
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2025-04-07
- **Primary completion:** 2025-12-30
- **Final completion:** 2025-12-30
- **Target enrollment:** 45 (ACTUAL)
- **Last updated:** 2026-02-03

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06871904

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06871904, "Fibrosis-Modulating Effects of Metformin and Pirfenidone in Oral Submucous Fibrosis". Retrieved via AI Analytics 2026-06-26 from https://api.ai-analytics.org/clinical/NCT06871904. Licensed CC0.

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