# Concomitant Treatment with Topical Hyaluronic Acid and High Concentration Oxygen Therapy (Vaginal Natural Oxygenation Device - VNOD) in the Improvement of Symptoms Related to Genitourinary Syndrome of Menopause in Women with Natural and Oncological Postmenopause: Open-Label, Single-Center, Randomize

> **NCT06879938** · NA · RECRUITING · sponsor: **Fondazione IRCCS Policlinico San Matteo di Pavia** · enrollment: 80 (estimated)

## Conditions studied

- Genitourinary Syndrome of Menopause

## Interventions

- **DEVICE:** High-concentration vaginal oxygen therapy (Caress Flow) with topical hyaluronic acid
- **DEVICE:** hyaluronic acid-based gel (Hydeal-D®)

## Key facts

- **NCT ID:** NCT06879938
- **Lead sponsor:** Fondazione IRCCS Policlinico San Matteo di Pavia
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2023-10-16
- **Primary completion:** 2025-12
- **Final completion:** 2025-12
- **Target enrollment:** 80 (ESTIMATED)
- **Last updated:** 2025-03-17


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06879938

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06879938, "Concomitant Treatment with Topical Hyaluronic Acid and High Concentration Oxygen Therapy (Vaginal Natural Oxygenation Device - VNOD) in the Improvement of Symptoms Related to Genitourinary Syndrome of Menopause in Women with Natural and Oncological Postmenopause: Open-Label, Single-Center, Randomize". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT06879938. Licensed CC0.

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