# Long-term Safety of Nipple Sparing Mastectomy in Women With High Penetrance Breast Cancer Susceptibility Genes in Breast Cancer

> **NCT06888388** · — · RECRUITING · sponsor: **Sir Mortimer B. Davis - Jewish General Hospital** · enrollment: 4700 (estimated)

## Conditions studied

- Breast Cancer Surgery

## Interventions

- **PROCEDURE:** Nipple Sparing Mastectomy (NSM)
- **PROCEDURE:** Skin-Sparing Mastectomy (SSM)
- **PROCEDURE:** Total (Simple) Mastectomy

## Key facts

- **NCT ID:** NCT06888388
- **Lead sponsor:** Sir Mortimer B. Davis - Jewish General Hospital
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** RECRUITING
- **Start date:** 2025-02-01
- **Primary completion:** 2027-02-01
- **Final completion:** 2028-02-01
- **Target enrollment:** 4700 (ESTIMATED)
- **Last updated:** 2025-12-08

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06888388

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06888388, "Long-term Safety of Nipple Sparing Mastectomy in Women With High Penetrance Breast Cancer Susceptibility Genes in Breast Cancer". Retrieved via AI Analytics 2026-07-05 from https://api.ai-analytics.org/clinical/NCT06888388. Licensed CC0.

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