# Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer

> **NCT06910761** · PHASE2 · RECRUITING · sponsor: **City of Hope Medical Center** · enrollment: 35 (estimated)

## Conditions studied

- Anatomic Stage IV Breast Cancer AJCC v8
- Metastatic Breast Carcinoma
- Metastatic Lung Non-Small Cell Carcinoma
- Metastatic Malignant Neoplasm in the Leptomeninges
- Stage IV Lung Cancer AJCC v8

## Interventions

- **PROCEDURE:** Biospecimen Collection
- **RADIATION:** Craniospinal Irradiation
- **OTHER:** Electronic Health Record Review
- **PROCEDURE:** Lumbar Puncture
- **PROCEDURE:** Magnetic Resonance Imaging
- **PROCEDURE:** Ommaya Reservoir Tap
- **OTHER:** Questionnaire Administration
- **RADIATION:** Volume Modulated Arc Therapy

## Key facts

- **NCT ID:** NCT06910761
- **Lead sponsor:** City of Hope Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-05-05
- **Primary completion:** 2028-10-02
- **Final completion:** 2028-10-02
- **Target enrollment:** 35 (ESTIMATED)
- **Last updated:** 2025-12-08

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06910761

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06910761, "Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer". Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/clinical/NCT06910761. Licensed CC0.

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