# The Effect and Safety of Anti-inflammatories and Dextrose Prolotherapy Injections in Treating Knee Osteoarthritis

> **NCT06911359** · PHASE2 · RECRUITING · sponsor: **David Grant U.S. Air Force Medical Center** · enrollment: 68 (estimated)

## Conditions studied

- Knee Osteoarthritis (OA)

## Interventions

- **DRUG:** Participants are given Ibuprofen 400 mg to take for 7 days on the day they receive a dextrose prolotherapy (DPT) injection. These procedures are repeated every 3-5 weeks for a total of 3 times.
- **DRUG:** Participants are given a placebo to take for 7 days on the day they receive a dextrose prolotherapy (DPT) injection. These procedures are repeated every 3-5 weeks for a total of 3 times.

## Key facts

- **NCT ID:** NCT06911359
- **Lead sponsor:** David Grant U.S. Air Force Medical Center
- **Sponsor class:** FED
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-03-31
- **Primary completion:** 2026-12-31
- **Final completion:** 2026-12-31
- **Target enrollment:** 68 (ESTIMATED)
- **Last updated:** 2025-11-24


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06911359

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06911359, "The Effect and Safety of Anti-inflammatories and Dextrose Prolotherapy Injections in Treating Knee Osteoarthritis". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT06911359. Licensed CC0.

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