# Comparative Effectiveness of Tirzepatide Versus Semaglutide in Individuals With Heart Failure With Preserved Ejection Fraction

> **NCT06914141** · — · COMPLETED · sponsor: **Brigham and Women's Hospital** · enrollment: 28118 (actual)

## Conditions studied

- Diabetes Mellitus, Type 2
- HFpEF - Heart Failure With Preserved Ejection Fraction

## Interventions

- **DRUG:** Tirzepatide
- **DRUG:** Semaglutide

## Key facts

- **NCT ID:** NCT06914141
- **Lead sponsor:** Brigham and Women's Hospital
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** COMPLETED
- **Start date:** 2025-01-14
- **Primary completion:** 2025-06-01
- **Final completion:** 2025-06-01
- **Target enrollment:** 28118 (ACTUAL)
- **Last updated:** 2026-01-30


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06914141

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06914141, "Comparative Effectiveness of Tirzepatide Versus Semaglutide in Individuals With Heart Failure With Preserved Ejection Fraction". Retrieved via AI Analytics 2026-06-26 from https://api.ai-analytics.org/clinical/NCT06914141. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*