# A Phase ll Study of Neoadjuvant Short-course Radiotherapy Followed by Ivonescimab and Chemotherapy in pMMR/MSS Locally Advanced Rectal Cancer

> **NCT06919510** · PHASE2 · NOT_YET_RECRUITING · sponsor: **Sun Yat-sen University** · enrollment: 90 (estimated)

## Conditions studied

- Rectal Adenocarcinoma

## Interventions

- **DRUG:** lvonescimab
- **DRUG:** CAPOX (oxaliplatin/capecitabine)
- **RADIATION:** radiotherapy
- **PROCEDURE:** Surgery or watch&wait

## Key facts

- **NCT ID:** NCT06919510
- **Lead sponsor:** Sun Yat-sen University
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2025-04-01
- **Primary completion:** 2026-06-01
- **Final completion:** 2028-12-01
- **Target enrollment:** 90 (ESTIMATED)
- **Last updated:** 2025-04-09

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06919510

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06919510, "A Phase ll Study of Neoadjuvant Short-course Radiotherapy Followed by Ivonescimab and Chemotherapy in pMMR/MSS Locally Advanced Rectal Cancer". Retrieved via AI Analytics 2026-06-26 from https://api.ai-analytics.org/clinical/NCT06919510. Licensed CC0.

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