# Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of Relapse

> **NCT06928662** · PHASE1,PHASE2 · RECRUITING · sponsor: **Fred Hutchinson Cancer Center** · enrollment: 36 (estimated)

## Conditions studied

- Acute Myeloid Leukemia
- Acute Undifferentiated Leukemia
- Mixed Phenotype Acute Leukemia
- Recurrent Acute Myeloid Leukemia
- Recurrent Acute Undifferentiated Leukemia
- Recurrent Chronic Myelomonocytic Leukemia
- Recurrent Mixed Phenotype Acute Leukemia
- Recurrent Myelodysplastic Syndrome
- Refractory Acute Myeloid Leukemia
- Refractory Acute Undifferentiated Leukemia
- Refractory Chronic Myelomonocytic Leukemia
- Refractory Mixed Phenotype Acute Leukemia
- Refractory Myelodysplastic Syndrome
- Secondary Acute Myeloid Leukemia

## Interventions

- **DRUG:** Decitabine
- **PROCEDURE:** Bone Marrow Aspiration
- **PROCEDURE:** Bone Marrow Biopsy
- **PROCEDURE:** Chest Radiography
- **DRUG:** Cytarabine
- **PROCEDURE:** Echocardiography Test
- **BIOLOGICAL:** Filgrastim
- **DRUG:** Fludarabine
- **PROCEDURE:** Hematopoietic Cell Transplantation
- **DRUG:** Idarubicin
- **PROCEDURE:** Multigated Acquisition Scan
- **PROCEDURE:** Pheresis
- **RADIATION:** Total-Body Irradiation
- **PROCEDURE:** Biospecimen Collection

## Key facts

- **NCT ID:** NCT06928662
- **Lead sponsor:** Fred Hutchinson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-09-23
- **Primary completion:** 2028-03-09
- **Final completion:** 2028-11-29
- **Target enrollment:** 36 (ESTIMATED)
- **Last updated:** 2026-05-15


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06928662

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06928662, "Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of Relapse". Retrieved via AI Analytics 2026-07-03 from https://api.ai-analytics.org/clinical/NCT06928662. Licensed CC0.

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