# Neurobiological Mechanisms of Pathological Rumination and Effects of Aripiprazole

> **NCT06937476** · NA · ACTIVE_NOT_RECRUITING · sponsor: **Central South University** · enrollment: 108 (estimated)

## Conditions studied

- Major Depressive Disorder (MDD)
- Rumination

## Interventions

- **DRUG:** Escitalopram
- **DRUG:** Aripiprazole 5mg

## Key facts

- **NCT ID:** NCT06937476
- **Lead sponsor:** Central South University
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2025-05-08
- **Primary completion:** 2026-04-08
- **Final completion:** 2026-05-01
- **Target enrollment:** 108 (ESTIMATED)
- **Last updated:** 2026-04-16

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06937476

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06937476, "Neurobiological Mechanisms of Pathological Rumination and Effects of Aripiprazole". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT06937476. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*