# Analysis of the Role of AIRE in Autoimmune Neurological Diseases Associated With Autoantibodies

> **NCT06941584** · — · RECRUITING · sponsor: **Fondazione Policlinico Universitario Agostino Gemelli IRCCS** · enrollment: 40 (estimated)

## Conditions studied

- AIRE Deficiency

## Interventions

- **DIAGNOSTIC_TEST:** Test for AQP4, AChR, LGI1, and CASPR2 autoantibodies using cell-based assay
- **GENETIC:** AIRE single gene sequencing
- **GENETIC:** Molecular typing of HLA class I and II alleles

## Key facts

- **NCT ID:** NCT06941584
- **Lead sponsor:** Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** RECRUITING
- **Start date:** 2024-11-06
- **Primary completion:** 2027-01-06
- **Final completion:** 2027-01-06
- **Target enrollment:** 40 (ESTIMATED)
- **Last updated:** 2025-04-24

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06941584

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06941584, "Analysis of the Role of AIRE in Autoimmune Neurological Diseases Associated With Autoantibodies". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT06941584. Licensed CC0.

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