# Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation

> **NCT06942039** · EARLY_PHASE1 · RECRUITING · sponsor: **C17 Council** · enrollment: 15 (estimated)

## Conditions studied

- CNS Embryonal Tumor
- CNS, Medulloblastoma
- Atypical Teratoid Rhabdoid Tumor
- Medulloblastoma, Childhood
- Medulloblastoma, Group 3
- Medulloblastoma, Group 4
- Pineoblastoma
- Neuroblastoma
- Embryonal Tumor With Multilayered Rosettes
- Embryonal Tumor With Abundant Neuropil and True Rosettes
- Ependymoblastoma
- Medulloepithelioma
- CNS Embryonal Tumor With Rhabdoid Features
- CNS Embryonal Tumor, Nos

## Interventions

- **DRUG:** Cytarabine IT
- **DRUG:** hydrocortisone
- **DRUG:** Cisplatin
- **DRUG:** Vincristine
- **DRUG:** Etoposide
- **DRUG:** Cyclophosphamide
- **DRUG:** Mesna
- **DRUG:** Filgrastim
- **DRUG:** carboplatin
- **DRUG:** Thiotepa
- **DRUG:** Topotecan IT
- **DRUG:** Tamoxifen
- **DRUG:** ISOtretinoin
- **DRUG:** Celecoxib
- **DRUG:** etoposide phosphate
- **DRUG:** Temozolomide

## Key facts

- **NCT ID:** NCT06942039
- **Lead sponsor:** C17 Council
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-09-23
- **Primary completion:** 2030-12-31
- **Final completion:** 2032-12-31
- **Target enrollment:** 15 (ESTIMATED)
- **Last updated:** 2026-02-27


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06942039

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06942039, "Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation". Retrieved via AI Analytics 2026-09-28 from https://api.ai-analytics.org/clinical/NCT06942039. Licensed CC0.

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