# CASCADE 2002: PROTECT Study, "PRObiotics to TrEat Anal preCancer Trial

> **NCT06949800** · PHASE2 · NOT_YET_RECRUITING · sponsor: **University of California, San Francisco** · enrollment: 90 (estimated)

## Conditions studied

- HSIL, High Grade Squamous Intraepithelial Lesion
- HPV-Related Squamous Cell Carcinoma
- Anal HSIL

## Interventions

- **DRUG:** EXE-346 Probiotic
- **DRUG:** Placebo
- **PROCEDURE:** Usual Care High Resolution Anoscopy (HRA)

## Key facts

- **NCT ID:** NCT06949800
- **Lead sponsor:** University of California, San Francisco
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-06-01
- **Primary completion:** 2027-04-30
- **Final completion:** 2027-05-31
- **Target enrollment:** 90 (ESTIMATED)
- **Last updated:** 2026-05-01

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06949800

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06949800, "CASCADE 2002: PROTECT Study, "PRObiotics to TrEat Anal preCancer Trial". Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/clinical/NCT06949800. Licensed CC0.

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