# A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder

> **NCT06951698** · PHASE3 · RECRUITING · sponsor: **Bristol-Myers Squibb** · enrollment: 274 (estimated)

## Conditions studied

- Bipolar-I Disorder With Mania or Mania With Mixed Features

## Interventions

- **DRUG:** KarXT
- **OTHER:** Placebo

## Key facts

- **NCT ID:** NCT06951698
- **Lead sponsor:** Bristol-Myers Squibb
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-06-11
- **Primary completion:** 2026-11-01
- **Final completion:** 2026-11-01
- **Target enrollment:** 274 (ESTIMATED)
- **Last updated:** 2026-04-14


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06951698

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06951698, "A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT06951698. Licensed CC0.

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