# Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

> **NCT06958328** · PHASE3 · RECRUITING · sponsor: **NRG Oncology** · enrollment: 356 (estimated)

## Conditions studied

- Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma
- Stage II Pancreatic Cancer AJCC v8
- Stage III Pancreatic Cancer AJCC v8
- Stage IV Pancreatic Cancer AJCC v8

## Interventions

- **PROCEDURE:** Biopsy Procedure
- **PROCEDURE:** Biospecimen Collection
- **DRUG:** Capecitabine
- **PROCEDURE:** Computed Tomography
- **RADIATION:** Dose-escalated Radiation Therapy
- **DRUG:** Fluorouracil
- **DRUG:** Gemcitabine
- **DRUG:** Irinotecan Hydrochloride
- **DRUG:** Irinotecan Sucrosofate
- **DRUG:** Leucovorin Calcium
- **PROCEDURE:** Magnetic Resonance Imaging
- **DRUG:** Nab-paclitaxel
- **OTHER:** Observation Activity
- **DRUG:** Oxaliplatin
- **PROCEDURE:** Positron Emission Tomography
- **OTHER:** Questionnaire Administration
- **RADIATION:** Radiation Therapy

## Key facts

- **NCT ID:** NCT06958328
- **Lead sponsor:** NRG Oncology
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-08-21
- **Primary completion:** 2030-10-21
- **Final completion:** 2030-10-21
- **Target enrollment:** 356 (ESTIMATED)
- **Last updated:** 2026-05-04


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06958328

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06958328, "Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT06958328. Licensed CC0.

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