# Node-Sparing Short-Course Radiotherapy Sequential Chemotherapy and PD-1 Inhibitor for Mid/Low pMMR/MSS Rectal Cancer (MODIFI-RC-II)

> **NCT06958432** · PHASE2,PHASE3 · RECRUITING · sponsor: **Sixth Affiliated Hospital, Sun Yat-sen University** · enrollment: 430 (estimated)

## Conditions studied

- Rectal Cancer
- Neoadjuvant Therapies
- Immune Checkpoint Therapy
- Radiotherapy

## Interventions

- **COMBINATION_PRODUCT:** Node-Sparing Radiotherapy plus Chemotherapy and PD-1 inhibitor
- **COMBINATION_PRODUCT:** Conventional Radiotherapy plus Chemotherapy and PD-1 inhibitor

## Key facts

- **NCT ID:** NCT06958432
- **Lead sponsor:** Sixth Affiliated Hospital, Sun Yat-sen University
- **Sponsor class:** OTHER
- **Phase:** PHASE2,PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-05-01
- **Primary completion:** 2030-12-31
- **Final completion:** 2031-12-31
- **Target enrollment:** 430 (ESTIMATED)
- **Last updated:** 2025-08-07


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06958432

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06958432, "Node-Sparing Short-Course Radiotherapy Sequential Chemotherapy and PD-1 Inhibitor for Mid/Low pMMR/MSS Rectal Cancer (MODIFI-RC-II)". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT06958432. Licensed CC0.

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