# Role of the Blood-Brain Barrier in Stress Resilience: Investigating New Pathways Towards Pharmacological Augmentation of Stress Resilience

> **NCT06965868** · NA · NOT_YET_RECRUITING · sponsor: **Leibniz-Institut für Resilienzforschung (LIR) gGmbH** · enrollment: 122 (estimated)

## Conditions studied

- Stress Resilience
- Blood-Brain Barrier Integrity
- Mental Health

## Interventions

- **DRUG:** Metformin
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT06965868
- **Lead sponsor:** Leibniz-Institut für Resilienzforschung (LIR) gGmbH
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2025-06
- **Primary completion:** 2027-02
- **Final completion:** 2027-02
- **Target enrollment:** 122 (ESTIMATED)
- **Last updated:** 2025-05-11

## Collaborators

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- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06965868

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06965868, "Role of the Blood-Brain Barrier in Stress Resilience: Investigating New Pathways Towards Pharmacological Augmentation of Stress Resilience". Retrieved via AI Analytics 2026-07-06 from https://api.ai-analytics.org/clinical/NCT06965868. Licensed CC0.

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