# The 'Bone-Brain' Crosstalk Mechanism of Subchondral Bone Nociceptive Sensitization Activating SPP1-Positive Microglia in the vlPAG Region Elucidates the Theoretical Connotation of Treating Knee Osteoarthritis Based on Kidney Differentiation

> **NCT06977282** · — · NOT_YET_RECRUITING · sponsor: **Jinchao Xu** · enrollment: 120 (estimated)

## Conditions studied

- Osteoarthitis

## Interventions

_None listed._

## Key facts

- **NCT ID:** NCT06977282
- **Lead sponsor:** Jinchao Xu
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2025-06-15
- **Primary completion:** 2026-12-30
- **Final completion:** 2026-12-30
- **Target enrollment:** 120 (ESTIMATED)
- **Last updated:** 2025-05-18


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06977282

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06977282, "The 'Bone-Brain' Crosstalk Mechanism of Subchondral Bone Nociceptive Sensitization Activating SPP1-Positive Microglia in the vlPAG Region Elucidates the Theoretical Connotation of Treating Knee Osteoarthritis Based on Kidney Differentiation". Retrieved via AI Analytics 2026-06-23 from https://api.ai-analytics.org/clinical/NCT06977282. Licensed CC0.

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