# A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) During Analytic Treatment Interruption in Participants Living With HIV Who Initiated ART During Acute/Early HIV-1 Infection

> **NCT06987318** · PHASE1 · NOT_YET_RECRUITING · sponsor: **National Institute of Allergy and Infectious Diseases (NIAID)** · enrollment: 40 (estimated)

## Conditions studied

- HIV-1-infection

## Interventions

- **BIOLOGICAL:** VRC07-523LS
- **BIOLOGICAL:** PGT121.414.LS

## Key facts

- **NCT ID:** NCT06987318
- **Lead sponsor:** National Institute of Allergy and Infectious Diseases (NIAID)
- **Sponsor class:** NIH
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-06-12
- **Primary completion:** 2027-08-29
- **Final completion:** 2028-05-07
- **Target enrollment:** 40 (ESTIMATED)
- **Last updated:** 2026-04-03

## Collaborators

- Monogram Biosciences

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06987318

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06987318, "A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) During Analytic Treatment Interruption in Participants Living With HIV Who Initiated ART During Acute/Early HIV-1 Infection". Retrieved via AI Analytics 2026-06-08 from https://api.ai-analytics.org/clinical/NCT06987318. Licensed CC0.

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