# Lifestyle Interventions to Prevent Cognitive Deficits in Subjects With Depressive Symptoms: From Mechanisms to Clinical Practice

> **NCT07009223** · NA · RECRUITING · sponsor: **IRCCS Centro San Giovanni di Dio Fatebenefratelli** · enrollment: 120 (estimated)

## Conditions studied

- Major Depressive Disorder (MDD)
- Physical Activity
- Inflammation
- Metabolome
- Gut Microbiota
- Depressive Symptoms

## Interventions

- **BEHAVIORAL:** Mediterranean Diet
- **BEHAVIORAL:** Physical Activity
- **BEHAVIORAL:** Cognitive Training

## Key facts

- **NCT ID:** NCT07009223
- **Lead sponsor:** IRCCS Centro San Giovanni di Dio Fatebenefratelli
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-10-01
- **Primary completion:** 2026-08
- **Final completion:** 2028-03
- **Target enrollment:** 120 (ESTIMATED)
- **Last updated:** 2026-02-11

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07009223

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07009223, "Lifestyle Interventions to Prevent Cognitive Deficits in Subjects With Depressive Symptoms: From Mechanisms to Clinical Practice". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT07009223. Licensed CC0.

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