# Switching Medication and Augmentation Strategies for SSRI-Resistant Adolescent Depression（SMART-I)

> **NCT07011693** · PHASE4 · NOT_YET_RECRUITING · sponsor: **Xinyu Zhou** · enrollment: 400 (estimated)

## Conditions studied

- Major Depressive Disorder (MDD)

## Interventions

- **DRUG:** Sertraline
- **DRUG:** Agomelatine
- **DRUG:** Aripiprazole

## Key facts

- **NCT ID:** NCT07011693
- **Lead sponsor:** Xinyu Zhou
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2025-06-20
- **Primary completion:** 2027-06
- **Final completion:** 2027-12
- **Target enrollment:** 400 (ESTIMATED)
- **Last updated:** 2025-06-10


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT07011693

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT07011693, "Switching Medication and Augmentation Strategies for SSRI-Resistant Adolescent Depression（SMART-I)". Retrieved via AI Analytics 2026-06-23 from https://api.ai-analytics.org/clinical/NCT07011693. Licensed CC0.

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